The Botany of Desire: Michael Pollan

Michael Pollan, The Botany of Desire:

What... was the knowledge that God wanted to keep from Adam and Eve in the Garden? Theologians will debate this question without end, but it seems to me the most important answer is hidden in plain sight. The content of the knowledge Adam and Eve could gain by tasting of the fruit does not matter nearly as much as its form... from nature. The new faith sought to break the human bond with magic nature, to disenchant the world of plants and animals by directing our attention to a single God in the sky. Yet Jehovah couldn't very well pretend the tree of knowledge didn't exist, not when generations of plant-worshipping pagans knew better. So the pagan tree is allowed to grow even in Eden, though ringed around now with a strong taboo. Yes, there is spiritual knowledge in nature, the new God is acknowledging, and its temptations are fierce, but I am fiercer still. Yield to it, and you will be punished.

So unfolds the drug war's first battle.
"

Friday, October 1, 2010

California Gov. Arnold Schwarzenegger Decriminalizes Cannabis

San Francisco Gate

Citing the need to reduce spending on prosecution and courts, Gov. Arnold Schwarzenegger signed a measure that makes marijuana possession an infraction, on par with traffic and littering tickets.

The Republican governor's unexpected support for the measure comes one month before voters decide whether to legalize adult recreational use of marijuana in California.

"In this time of drastic budget cuts, prosecutors, defense attorneys, law enforcement and the courts cannot afford to expend limited resources prosecuting a crime that carries the same punishment as a traffic ticket," wrote Schwarzenegger, who opposes Proposition 19, the marijuana initiative.

The law, which takes effect immediately, reduces possession of up to an ounce of marijuana - about the amount that will fit in a sandwich-size bag - from a misdemeanor to an infraction. Already, marijuana possession was the only misdemeanor under California law that didn't allow for jail time.


edit to clarify/add

all laws passed in CA take effect on Jan. 1 of the next year so this law will not be in effect until that time.

here is a link to the bill

Denver Examiner

The new law will not take effect until January 1, 2011, and it will still remain relevant even if Proposition 19 passes.

Prop 19 leaves misdemeanor possession penalties in place for public use and smoking in the presence of children; under SB 1449, these offenses are now simple infractions. Leaving dispensary owners opposed to Prop 19 with one less objection.

California NORML originally called for making petty possession an infraction when the state passed its original landmark decriminalization law in 1975, but the Legislature made it a minor misdemeanor punishable by a maximum $100 fine.

This marks the first time in 35 years that penalties for non-medical use of marijuana have been reduced in California.

Tuesday, September 28, 2010

Drug Criminalization Structure Squanders $88 Billion PER YEAR

Weed Wars blog at the Sacramento Post

A new report, "The Budgetary Impact of Ending Drug Prohibition," has been published by Harvard economist Jeffrey A. Miron and Katherine Waldock, a PhD candidate at the Stern School of Business at New York University. This report has been published by The Cato Institute.
An announcement for Cato study asserts that the "drug criminalization structure" nationally "squanders a total of $88 billion a year - $41.3 billion spent to prosecute the 'war on drugs' and $46.7 billion in lost potential revenue from the taxation of legal drug sales."

A .pdf of the report is available at the link above.

Friday, September 24, 2010

Obama drug-policy adviser says the administration opposes marijuana legalization

...and isn't big on medical marijuana.

Billings Gazette

HELENA — The Obama administration adamantly opposes legalizing marijuana and has a dubious view of medical marijuana, a top White House drug policy adviser said here Thursday night.

Kevin Sabet, special adviser for policy at the White House’s Office of National Drug Control Policy, said marijuana is a dangerous drug that causes documented health and social problems, and should not be subject to voter approval for its use.

“Marijuana cannot be the one exception in history of the world that doesn’t go through a scientific process to be approved as medicine,” he told the Montana Supreme Court Administrator’s annual drug court conference in Helena. “It doesn’t make any sense.

“How can we imagine that a dangerous, illegal drug like marijuana should be voted on by the people? That’s not how we do medicine in this country.

...Sabet said he believes medical marijuana programs are part of a strategy to legalize marijuana, and that the Obama administration is staunchly opposed to legalization.”

...Sabet also said legalization proponents have created a “false dichotomy” by suggesting the only alternatives are legalization or a harsh, punitive approach that emphasizes incarceration.

Those aren’t the only options, and the Obama administration favors an approach that pairs treatment with law enforcement, to reduce illegal drug usage and addiction without sending people to prison, he said.

Sigh. So tired of these stale talking points.

Legal Cannabis is the Best Thing for Medical Marijuana Patients Since Prop. 215

In recent weeks some people in California have spoken out against Prop. 19 by declaring it hurts medical marijuana patients.

A medical marijuana and Prop. 19 supporter asked California attorney David Nick to comment.

For 18 years, David Nick has successfully litigated a cornucopia of issues regarding cannabis and the applicable laws in both trial and appellate courts. He has not confined his practice to marijuana law, but also litigates cases involving constitutional rights and criminal procedure.

David Nick has never lost a jury trial in a state marijuana case including many precedent setting trials involving some of the most revered figures in the medical marijuana movement such as Brownie Mary, Dennis Peron (Nick has been Peron’s sole attorney since 1994) and Steve Kubby.


Here's what Nick has to say:

PROP. 19 IS THE BEST THING TO HAPPEN TO MMJ PATIENTS SINCE PROP. 215

Anyone who claims that Proposition 19 will restrict or eliminate rights under the Compassionate Use Act (CUA) or the Medical Marijuana Program (MMP) is simply wrong. If anything, Proposition 19 will permit individuals to grow and possess much more than ever before with patients, coops and collectives still receiving the same protections they are entitled to under the CUA and MMP.

Here is why.

The legal arguments claiming the "sky will fall" if Prop. 19 passes are based on the fallacious conclusion that the Initiative invalidates the CUA and MMP. This baseless fear stems from a flawed legal analysis which focuses on just about every portion of Prop. 19 EXCEPT the relevant portions. This flawed legal analysis is driven by an incorrect understanding of the rules of statutory construction.

PROP. 19 PROVIDES ADDITIONAL PROTECTIONS TO PATIENTS FROM THE ACTIONS OF LOCAL GOVERNMENT AND LOCAL LAW ENFORCEMENT

Section 2B presents the controlling and relevant purposes for understanding what Prop. 19 can and cannot do. This section EXPRESSLY excludes the reach of Prop. 19 from the CUA and MMP. Sections 2B (7 & 8) specifically state that the purpose of this initiative is to give municipalities total and complete control over the commercial sales of marijuana "EXCEPT as permitted under Health and Safety Sections 11362.5 and 11362.7 through 11362.9.”


This is an email from the attorney. You can read the rest of it here

David Borden, Exec. Director of Stop the Drug War, brings this email to the attention of the larger public and notes that opposition is not across the board among those currently involved in the medical marijuana community.

Fortunately, only some medical marijuana people are so shortsighted as to oppose this historic and important measure. Harborside Health Center in Oakland, and the Berkeley Patients Group are among the top quality groups lending their support to Prop 19. But it's still worth asking, why are some other medical marijuana providers opposing it?

Famed Canadian Marc Emery, from his US prison cell offered the obvious explanation: money.


Of course, the answer could also be a misreading of the current Proposition or simply failing to read the language and arguments themselves among those who have joined those who put their financial gain above every person in this nation who stands to benefit from an end to the war on cannabis.

Wednesday, September 22, 2010

The Most Censored Health Story of This Century


Cannabis Cures Cancer

Project Censored, Top 25 Stories, 2001
The U.S. Government Attempted to Repress the Marijuana Cancer Research.
...The Madrid researcher (studying the tumor-reducing qualities of cannabinoids, noted in the post immediately below) said he had heard of the Virginia study, but had never been able to locate literature on it. “I am aware of the existence of that research. In fact I have attempted many times to obtain the journal article on the original investigation by theses people, but it has proven impossible,” Guzman said. His response wasn’t surprising, considering that in 1983 the Reagan/Bush administration tried to persuade American universities and researchers to destroy all 1966/76 cannabis research work, including compendiums in libraries, reports Jack Herer. “We know that large amounts of information have since disappeared,” he says.


Cured: A Cannabis Story

Antineoplastic Activity Of Cannabinoids

Journal of the National Cancer Institute, Vol. 55, No. 3, September 1975 (via the UK Cannabis Internet Activist)
Investigations into the physiologic processes affected by the psychoactive constitutuents of marihuana [delta-9-tetrahydrocannabinol (delta-9-THC) and delta-8-tetrahydrocannabinol (delta-8-THC)] purified from Cannabis sativa are extensive (1).

However, only recently have attempts been made to elucidate the biochemical basis for their cytotoxic or cytostatic activity. Leuchtenberger et al. (2) demonstrated that human lung cultures exposed to marihuana smoke showed alterations in DNA synthesis, with the appearance of anaphase bridges. (me: Anaphase bridges are one example of cancer cell abnormalities. Chromosomes are pulled in opposite directions by the spindle apparatus. This can result in double strand breaks that recombine as aberrations.)

A preliminary report from this laboratory (9) indicated that the ability of delta-9-THC to interfere with normal cell functions might prove efficacious against neoplasms. (me: an abnormal mass of tissue.) This report represents an effort to test various cannabinoids in several in vivo and in vitro tumor systems to determine the kinds of tumors that are sensitive to these compounds and reveal their possible biochemical sites of action(s).

...Delta-9-THC, delta-8-THC, and cannabinol (CBN) all inhibited primary Lewis lung tumor growth, whereas cannabidiol (CBD) enhanced tumor growth.

Oral administration of 25, 50, or 100 mg delta-9-THC/kg inhibited primary tumor growth by 48, 72, and 75% respectively, when measured 12 days post tumor inoculation (table 1)

This paper, published more than 25 years ago, indicates that cannabis is a first-line cancer treatment. The reason this information is not widely available is that there is little to no profit for anyone (other than those suffering from cancer and the ones who love them) in this knowledge. Cannabis is a naturally-occurring substance whose properties may not be copyrighted.

Researchers at Harvard published a study in 2007 that indicates cannabis cuts lung cancer tumors by 50%.

Science News
They say this is the first set of experiments to show that the compound, Delta-tetrahydrocannabinol (THC), inhibits EGF-induced growth and migration in epidermal growth factor receptor (EGFR) expressing non-small cell lung cancer cell lines. Lung cancers that over-express EGFR are usually highly aggressive and resistant to chemotherapy.

THC that targets cannabinoid receptors CB1 and CB2 is similar in function to endocannabinoids, which are cannabinoids that are naturally produced in the body and activate these receptors. The researchers suggest that THC or other designer agents that activate these receptors might be used in a targeted fashion to treat lung cancer.

Although the researchers do not know why THC inhibits tumor growth, they say the substance could be activating molecules that arrest the cell cycle. They speculate that THC may also interfere with angiogenesis and vascularization, which promotes cancer growth.

Research in Spain, published in 2009, demonstrated the mechanism by which cannabis induces cancer cell death.

Journal of Clinical Investigation
Δ9-Tetrahydrocannabinol (THC), the main active component of marijuana (7), exerts a wide variety of biological effects by mimicking endogenous substances — the endocannabinoids — that bind to and activate specific cannabinoid receptors (8). One of the most exciting areas of research in the cannabinoid field is the study of the potential application of cannabinoids as antitumoral agents (9). Cannabinoid administration has been found to curb the growth of several types of tumor xenografts in rats and mice (9, 10).

Based on this preclinical evidence, a pilot clinical trial has been recently run to investigate the antitumoral action of THC on recurrent gliomas (11). Recent findings have also shown that the pro-apoptotic and tumor growth–inhibiting activity of cannabinoids relies on the upregulation of the transcriptional co-activator p8 (12) and its target the pseudo-kinase tribbles homolog 3 (TRB3) (13).

However, the mechanisms that promote the activation of this signaling route as well as the targets downstream of TRB3 that mediate its tumor cell–killing action remain elusive. In this study we found that ER stress–evoked upregulation of the p8/TRB3 pathway induced autophagy via inhibition of the Akt/mTORC1 axis and that activation of autophagy promoted the apoptotic death of tumor cells. The uncovering of this pathway, which we believe is novel, for promoting tumor cell death may have therapeutic implications in the treatment of cancer.

California Breast Cancer Research Program (from Molecular Cancer Therapeutics)
An anti-cancer agent with a low toxicity profile that can both inhibit cancer cell growth and metastasis would be extremely valuable clinically. We have discovered that cannabidiol (CBD), a non-psychotropic cannabinoid constituent of the plant Cannabis sativa, can inhibit the growth, migration and invasion of aggressive breast cancer cells in culture.

Cannabinoid compounds, in general, have low toxicity profiles. Furthermore, our preliminary research demonstrated that CBD is a novel inhibitor of a protein whose activity has been closely linked to the aggressiveness of human breast cancers; called inhibitor of DNA binding-1 (Id-1). Whether CBD can inhibit the spread of metastatic breast cancer in vivo (in the body), compared to cell culture conditions, has not been determined.

However, CBD has been demonstrated to inhibit aggressive human brain cancers in vivo. Understanding the mechanisms behind the anti-cancer activity of CBD may lead to the validation of new biological targets for diagnostics and therapies for breast cancer.

Combining Cannabinoids Enhances Inhibition of Brain Cancer Cells
The study was done at the California Pacific Medical Center by researchers who combined a non-psychoactive ingredient of marijauna, cannabidiol (CBD), with Δ9-tetrahyrdocannabinol (Δ9-THC), the primary psychoactive ingredient in Cannabis. The findings demonstrated the inhibitory effect of these two ingredients on brain cancer cells when used together.

“Our study not only suggests that combining these two compounds creates a synergistic effect,” says Sean McAllister, Ph.D., a scientist at CPMCRI and the lead author of the study. “but it also helps identify molecular mechanisms at work here, and that may lead to more effective treatments for glioblastoma and potentially other aggressive cancers.”

It would seem that "magic nature," as noted in the Michael Pollan quote here, does indeed have knowledge to impart.

Beer Distributors Donate $10,000 to Keep Cannabis Illegal

Redding Record Spotlight

On Sept. 7, the California Beer & Beverage Distributors gave $10,000 to a committee opposing Proposition 19, the measure that would change state law to legalize pot and allow it to be taxed and regulated.

The California Police Chiefs Association has given the most to the Proposition 19 opposition with a contribution of $30,000, according to Cal-Access, a website operated by the secretary of state’s office.

“Unless the beer distributors in California have suddenly developed a philosophical opposition to the use of intoxicating substances, the motivation behind this contribution is clear,” Steve Fox, director of government relations for the Marijuana Policy Project, said in statement. “Plain and simple, the alcohol industry is trying to kill the competition. Their mission is to drive people to drink.”

No one from the Beer Pac was available for comment.

This isn't the first time the Beer lobbyists have worked to continue prohibition (irony duly noted... or rather, hypocrisy, or rather, the truth that prohibition is a financial fight, not only for the petrol and forestry industries, but for the alcoholic beverage industry as well.)

In 2008, "the California Beer and Beverage Distributors contributed $100,000 to the campaign against Proposition 5, the Nonviolent Offender Rehabilitation Act (NORA). This initiative proposed to, among other things, reduce the penalty for cannabis possession in California from a misdemeanor to an infraction, similar to a traffic ticket."

"...The original bill authorizing the National Youth Anti-Drug Media Campaign specifically banned the use of campaign funds to address underage drinking. In fact, when lawmakers attempted to amend the bill so that anti-alcohol messages could be included, the NBWA (National Beer Wholesalers Association) strongly opposed the amendment. To this day, the national Youth Anti-Drug Media Campaign has remained almost entirely alcohol-free."

Oh, btw, the NBWA gave more than $8 million to federal candidates between 2003 and 2008 "and ranked among the top five most generous PACs each cycle, reaching the no. 2 slot in 2005-6."

(From the book, Marijuana is Safer, pp. 90-91.)

hmmmm.